Your personal sphere of play:
- You will work on an experimental PhD project in the field of neurodegeneration, cellular neurotoxicity, and glial stress responses
- You will plan and conduct in vitro experiments with primary cells of the central nervous system, especially neurons and glial cells
- You will investigate the effects of toxic stimuli on cell viability, cell death, and cellular stress and inflammatory responses
- You will apply established cell biological, molecular biological, and microscopic methods and evaluate them quantitatively
- You will work with models of the blood-brain barrier to analyze barrier function and transport processes
- We expect the dissertation agreement to be completed within 12-18 months
- You will work continuously on your dissertation and its timely completion
- You will hold courses in accordance with the provisions of the collective agreement
- You will take on administrative tasks in research and teaching
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Your personal sphere of influence:
- Deep Biophysical Expertise: You have profound experience in ligand identification methods, specifically NMR, SPR, GCI, or nanoDSF.
- A Molecular Mindset: You possess a strong foundation in fragment-based drug design (FBDD) and medicinal chemistry. Prior experience or a keen interest in Targeted Protein Degradation (TPD) will give you a significant head start.
- Versatile Bench Skills: You are comfortable with essential cell biology techniques, including tissue culture, Western blotting, and flow cytometry.
- An Analytical Edge: You don’t just collect data; you enjoy the "puzzle." You possess sharp analytical thinking and the problem-solving skills required to navigate complex biological questions.
- Collaborative Spirit, Independent Drive: You thrive in a multidisciplinary team environment but are equally capable of managing your project independently.
- Communication Skills: You have a track record of clear scientific communication and strong writing skills.
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